The coiled - coil domain of MURC / Cavin - 4 is involved in membrane trafficking of 1 caveolin - 3 in cardiomyocytes
نویسندگان
چکیده
The coiled-coil domain of MURC/Cavin-4 is involved in membrane trafficking of 1 caveolin-3 in cardiomyocytes 2 3 Daisuke Naito, Takehiro Ogata, Tetsuro Hamaoka, Naohiko Nakanishi, Kotaro Miyagawa, 4 Naoki Maruyama, Takeru Kasahara, Takuya Taniguchi, Masahiro Nishi, Satoaki Matoba, 5 Tomomi Ueyama 6 7 Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto 8 Prefectural University of Medicine, Kyoto 602-8566, Japan 9 10 Running title: MURC/Cavin-4 functions as a crucial caveolar component 11 12 Address for reprint requests and other correspondence: Tomomi Ueyama and Takehiro 13 Ogata, Department of Cardiovascular Medicine, Graduate School of Medical Science, 14 Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, 15 Kamigyo-ku, Kyoto 602-8566, Japan 16 Tel.: +81-75-251-5511, Fax: +81-75-251-5514, E-mail: [email protected] (T. 17 Ueyama), [email protected] (T. Ogata) 18 19
منابع مشابه
The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes.
Muscle-restricted coiled-coil protein (MURC), also referred to as cavin-4, is a member of the cavin family that works cooperatively with caveolins in caveola formation and function. Cavins are cytoplasmic proteins with coiled-coil domains and form heteromeric complexes, which are recruited to caveolae in cells expressing caveolins. Among caveolins, caveolin-3 (Cav3) is exclusively expressed in ...
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The purpose of this study was to investigate whether MURC/cavin-4, a plasma membrane and Z-line associated protein exhibiting an overlapping distribution with Caveolin-3 (Cav-3) in heart and muscle tissues, may be expressed and play a role in rhabdomyosarcoma (RMS), an aggressive myogenic tumor affecting childhood. We found MURC/cavin-4 to be expressed, often concurrently with Cav-3, in mouse a...
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